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Overview
The NGS Targeted Capture Process involves using blockers for adapters to prevent the binding between adapter sequences in the library. Additionally, Cot-1 DNA is employed to block high-copy regions/low-complexity regions of library insert fragments, thereby preventing non-specific capturing of such regions caused by probe cross-hybridization.
 
By significantly reducing these two types of non-specific bindings, the on-target rate and data utilization can be improved. Dynegene Technology provides blocker reagents for targeted capture on both Illumina and MGI platforms. Moreover, they offer separate human Cot-1 DNA to support multiplexed hybridization, thus ensuring efficient capture for users.

 

Key Features

Blocking schematic

Blocker Working Process

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