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Overview
In the NGS targeted capture process, the use of blockers for adapters can prevent the binding between adapter sequences in the library, while Cot-1 DNA can block high-copy regions/low-complexity regions of library insert fragments, preventing non-specific capturing of such regions caused by probe cross-hybridization. By significantly reducing these two types of non-specific bindings, the on-target rate and data utilization can be improved. Dynegene Technologies provides the blocker reagents for targeted capture on both illumina and MGI platform, and also offers separate human Cot-1 DNA to support multiplexed hybridization, ensuring efficient capture for users.

Key Features

Blocking schematic

WPS图片(1)

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