The QuarXeq Human All Exon Probes 3.0 provide a comprehensive solution for whole exome sequencing. The probes are designed with reference to databases RefSeq, CCDS, and GENCODE for thorough coverage of CDS regions. It also takes into account common variations in the transcript forms of genes, and even the regions of the genome which is challenging to capture, such as the TERT promoter. The upgraded probes demonstrate exceptional performance in terms of capture efficiency and uniformity, making them ideal for applications in genetic disease detection, precision oncology and immunotherapy.