Whole Exome Sequencing (WES) leverages targeted capture technology to focus on protein-coding regions of the genome. Compared to whole-genome sequencing, WES offers more precise targeting, deeper coverage, and higher data accuracy - delivering an optimal balance of performance, efficiency, and cost-effectiveness.
Although the human exome represents only ~1% of the genome, it harbors approximately 85% of known disease-associated variants, making it a critical functional region. WES has therefore become a foundational tool across a wide range of applications, including genetic disease research, oncology companion diagnostics, pharmacogenomics, large-scale cohort studies, species identification, and paleogenomics.
Comprehensive Exome Solutions by Dynegene
Dynegene provides a versatile portfolio of human whole-exome solutions designed to meet diverse research and clinical needs. By optimizing key performance parameters - including capture efficiency, uniformity, sensitivity, accuracy, and cost - we enable researchers to achieve reliable and high-quality results across multiple application scenarios.
Exome Sequencing Workflow
Dynegene Human Exome Portfolio
● QuarStar Human All Exon Probes 4.0 (Standard)
• Designed based on the latest RefSeq, CCDS, and GENCODE databases, achieving
near-complete coverage of key reference regions；
• Advanced hybrid probe strategy combining high-performance dsDNA probes (enabled by single-base parallel amplification labeling technology) with chip-synthesized ssDNA probes；
• Supports flexible spike-in of customized target content for extended applications.
● QuarStar Human All Exon Probes 4.0 (Tumor)
• Optimized for oncology research with enhanced coverage of 1,000+ cancer-related genes, gene fusions, MSI, HRD, and HLA regions (~46 Mb total target region);
• AI-driven probe design, boosting strategies and high-performance dsDNA probe synthesis achieve a better bait-to-target ratio, enhancing capture specificity and uniformity while reducing sequencing burden and overall cost.
● QuarStar Human All Exon Probes 4.0 (Heredity)
• Comprehensive and up-to-date coverage: Leverages the latest versions of leading databases to achieve nearly 99.5% coverage of core exonic coding regions.
• More Stable Performance: Industry-leading GC bias control, exceptional on-target rates even at high coverage depths, precise coverage of differential regions, superior uniformity, and highly confident variant detection.
• Full-transcript coverage for over 40 frequently mutated complex genes improves detection of complex variants and rare diseases.
● QuarStar Human All Exon Probes 1.0
• Classic patented double-stranded RNA probes with upgraded manufacturing process.
• Building on the high detection rate of double-stranded RNA probes, our AI-powered boosting strategy further enhances capture performance while reducing data volume requirements.
• High data consistency, ideal for large cohorts and long-term research.
● QuarStar Human All Exon Probes 3.0（RNA）
• Comprehensive CDS region coverage based on RefSeq, CCDS, GENCODE and other databases.
• Delivers excellent performance in capture efficiency and uniformity, widely applicable for diagnosis of genetic disease, precision oncology, immunotherapy and other applications.
NGSHybridization Capture Probe NGS custom probes MRD custom probes QuarStar Human MethylCap Panel QuarStar Liquid Pan-Cancer Panel 3.0 QuarStar Pan-Cancer Lite Panel 3.0 QuarStar Pan-Cancer Fusion Panel 1.0 QuarStar Pan Cancer Panel 1.0 QuarStar Pan-Cancer Panel 1000-Gene QuarStar HLA Panel QuarXeq HRD panel QuarXeq Mitochondrial Probes Whole Exome Sequencing Probes QuarStar Human All Exon Probes 4.0 (Heredity) QuarStar Human All Exon Probes 4.0 (Tumor) QuarStar Human All Exon Probes 4.0 (Standard) QuarXeq Human All Exon Probes 1.0 (RNA) QuarXeq Human All Exon Probes 3.0 (RNA) Library Preparation DNA Library Preparation Kit Fragmentation Reagent mRNA Capture Kit rRNA Depletion Kit QuarPro Superfast T4 DNA Ligase Dynegene Adapter Family Hybridization Capture QuarHyb Super DNA Reagent Kit QuarHyb DNA Plus3 Reagent Kit QuarHyb DNA Reagent Kit Plus QuarHyb One Reagent Kit QuarHyb Super Reagent Kit Pro Dynegene Blocker Family QuarHyb DNA Reagent Kit Pro（Methyl） Multiplex PCR QuarMultiple BRCA Amplicon QuarMultiple PCR Capture Kit 2.0 PathoSeq 450 Pathogen Library Corollary Reagent Streptavidin magnetic beads Equipment and Software The iQuars50 NGS Prep System
Primers and Probes
RNA SynthesissgRNA miRNA siRNA
Gene
Oligo Pools
CRISPR sgRNA Library
Antibody Library
Variant Library
Tel: 400-017-9077
Address: Floor 2, Building 5, No. 248 Guanghua Road, Minhang District, Shanghai
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