Antibody Library Construction & Screening: Dynegene's Expertise in Advancing Antibody Discovery

Dynegene Technologies, a pioneering leader in the synthetic biology industry based in Shanghai, China, is revolutionizing antibody discovery and optimization through its state-of-the-art antibody library construction and screening capabilities. Established in 2018, Dynegene has quickly gained recognition as the only enterprise in China capable of commercializing ultra-high-throughput next-generation DNA synthesis.

The Crucial Role of Advanced DNA Synthesis in Antibody Discovery

The development of highly diverse and high-quality antibody libraries is paramount for the success of antibody discovery and optimization projects. Advanced DNA synthesis technologies, such as those employed by Dynegene, enable the construction of vast antibody libraries with unparalleled diversity and complexity. This increased diversity greatly enhances the chances of identifying novel antibodies with desired properties, such as high affinity, specificity, and stability.

Dynegene's ultra-high-throughput DNA synthesis platform allows for the rapid and cost-effective generation of billions of unique antibody sequences. This scalability is essential for exploring the immense potential of the antibody repertoire and accelerating the discovery of lead candidates for various applications, including therapeutics, diagnostics, and research tools. By leveraging cutting-edge nucleic acid synthesis technology, Dynegene empowers researchers and organizations to push the boundaries of antibody discovery and development.

Dynegene's Expertise in Antibody Library Construction

Dynegene specializes in the construction of high-quality antibody libraries using cutting-edge methods and technologies:

Naive Antibody Libraries

• Derived from B cells of non-immunized donors, providing a vast pool of antibody diversity
• Access to antibodies against virtually any target without the need for immunization or antigen preparation
• Potential for discovering rare and unique antibodies with novel functionalities

Dynegene's naive antibody libraries offer an invaluable resource for researchers seeking to identify antibodies against challenging targets or explore the natural antibody repertoire. By harnessing the power of custom oligo pools, Dynegene can generate highly diverse naive libraries that maximize the chances of discovering antibodies with desired properties.

Synthetic Antibody Libraries

• Created using in vitro molecular biology techniques to generate controlled diversity
• Precise control over library design and composition, enabling targeting of specific epitopes or binding sites
• Increased probability of isolating high-affinity binders due to optimized library design

Dynegene's expertise in synthetic antibody library construction allows for the creation of custom libraries tailored to specific project requirements. By carefully synthesizing antibody sequences, Dynegene can generate libraries enriched for desired characteristics, such as improved stability, enhanced affinity, or reduced immunogenicity. This level of control and precision is crucial for the success of antibody discovery projects targeting challenging antigens or aiming to develop therapeutic antibodies with optimal properties.

scFv and Fab Libraries

• Single-chain variable fragment (scFv) and antigen-binding fragment (Fab) libraries constructed in multiple formats
• Smaller size enables higher library diversity and compatibility with phage display screening
• Fab format retains natural antibody structure, allowing for better stability and downstream development

Dynegene's proficiency in constructing scFv and Fab libraries provides researchers with versatile tools for antibody discovery. These smaller antibody fragments offer several advantages, including increased library diversity, improved expression in bacterial systems, and compatibility with powerful screening technologies like phage display. By leveraging Dynegene's expertise in variant library construction, researchers can access high-quality scFv and Fab libraries that accelerate the identification of lead antibody candidates.

 

Partnering with Dynegene: Your Trusted Ally in Antibody Discovery

With its state-of-the-art facilities, expert team, and commitment to innovation, Dynegene is well-positioned to tackle the most challenging antibody discovery projects. As a trusted partner for organizations in the synthetic biology field, Dynegene empowers its clients to accelerate their research and development efforts, ultimately bringing life-changing products to market faster.

By collaborating with Dynegene, researchers and organizations gain access to:

• Cutting-edge antibody library construction technologies, including naive, synthetic, scFv, and Fab libraries
• Expertise in antibody optimization, including affinity maturation and reformatting
• Dedicated project support from a team of experienced scientists and engineers
• Flexible partnership models tailored to specific project requirements and timelines

Contact Dynegene today to learn how our antibody library construction expertise can help you achieve your antibody discovery and optimization goals.