MRD is a promising biomarker that enables early prediction of tumor recurrence and metastasis, rapid assessment of treatment response, improved prognostic stratification, and informed treatment decisions. The value of MRD testing lies not only in identifying patients who need treatment but also in confidently identifying those who do not. Ultimately, MRD testing can help improve patient survival rates and deliver better long-term outcomes.
Dynegene offers high-throughput chip-based custom probe synthesis for MRD detection. Combined with the WES4.0 Tumor Panel, we provide a complete solution for downstream MRD applications.
Highlights
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Ultra-high redundancy synthesis - zero probe omission
Our high-throughput DNA probe synthesis platform randomly and repeatedly arranges each probe sequence across multiple synthesis spots, ensuring every probe is redundantly synthesized at least 100 times. As a result, the probability of omission for any single probe is virtually zero. Additionally, multiple rounds of synthesis for each sequence significantly improve probe concentration uniformity, leading to more balanced NGS capture performance.
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dsDNA probes with ultra-high biotin labeling efficiency
Dynegene's high-throughput dsDNA probes use proprietary labeling technology, achieving up to 95% biotin modification efficiency. This delivers superior capture performance, especially for small MRD panels.
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Flexible combination solutions
Co-synthesis with off-the-shelf panels significantly reduces synthesis costs, minimizes batch-to-batch variation, and eliminates the risk of probe mixing errors in each experiment.
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Ultra-low cost - supporting multiple cost options
1. Traditional column-based synthesis: Costs about $4.48–$7.47 per probe.
2. High-throughput MRD probe synthesis: Reduces the cost per probe to ~$0.45 for panels with ≤300 probes.
3. High-throughput MRD probe synthesis
with Ultra-Low Cost: Supports simultaneous synthesis of customized sites for up to 20 patients, with a cost as low as ~$0.045 per probe.
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Industry-leading turnaround time
Can be ready to dispatch as fast as 4-6 working days.
Workflow of High-throughput MRD probe synthesis with Ultra-Low Cost
