Whole-genome bisulfite sequencing (WGBS) is widely regarded as the “gold standard” for DNA methylation research. However, at the whole-genome scale, it requires extremely high sequencing depth and large data volumes, resulting in substantial overall costs. Although methylation arrays offer single-base resolution, the number of probes is limited and typically focuses only on classical CpG sites.

In comparison, methylation probe capture technology enriches specific CpG regions using customized probes, enabling coverage of millions of sites and achieving a better balance among coverage breadth, detection resolution, and cost-effectiveness.

By optimizing probe design, Dynegene has launched the Ultra-Large Panel for Human Methylome Research - QuarStar Human MethylCap Panel. This panel targets 161 Mb of the human genome, incorporating approximately 1.8 million probes to capture 4.84 million CpG sites with well-defined biological significance. Combined with Dynegene’s methylation-specific blocking reagent and hybridization capture reagents, this ultra-large panel provides an ideal tool for systematic research in early cancer screening, aging studies, developmental biology, and epigenomics.